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费里基因基准区间的起源:一个系统的审查

Judy Truong1, Kanza Naveed1, Daniel Beriault2

  • 1Department of Medicine Canada, University of Toronto, Ontario, Canada.

The Lancet. Haematology
|June 27, 2024
PubMed
概括

血清费里的正常水平的实验室下限可能导致铁缺乏症的诊断不足. 这次系统性审查发现,当前的参考间隔通常基于有偏见的数据,缺乏严格的科学证据.

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...