尿路微生物群社区类型与女性尿失禁严重程度相关
Megan U Carnes1, Nazema Y Siddiqui2, Lisa Karstens3
1Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC.
American journal of obstetrics and gynecology
|June 27, 2024
概括
尿路微生物群较少多样化,乳酸菌较少,与女性尿失禁发作增加有关. 这一发现表明多巴组在失禁严重性的潜在作用.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 妇科 妇科医生 妇科
背景情况:
- 之前的研究确定了混合尿失禁妇女的尿道微生物群中的特定种群和社区差异.
- 一个假设提出,更高的尿液和阴道微生物群多样性与尿失禁严重程度的增加有关.
研究的目的:
- 研究特定的尿路或阴道微生物群类型与混合性尿失禁妇女尿失禁严重程度之间的关联.
主要方法:
- 从混合性尿失禁试验中进行了手术治疗效果与运动增强的参与者子集的横截面分析.
- 在基线收集尿液和阴道样本进行16SrRNA测序,以表征细菌种群.
- 尿失禁的严重程度是通过膀日记和尿路麻烦清单问卷进行评估的.
- 迪里克莱特多项混合物被用来将样本分为社区类型,线性回归模型分析了与严重程度指标的关联.
主要成果:
- 确定了六种尿道微生物群体类型. 与乳杆菌占主导地位的基准组 (76% Lactobacillus) 相比,一个乳杆菌丰度较低 (19%) 和α多样性较高的社区与更多的总发作 (每天2.67个发作) 和紧急性 (每天1.75个发作) 尿失禁发作有关.
- 尿路微生物组丰富与失禁发作增加有关 (P=.01).
- 阴道社区类型和微生物群均度措施与尿失禁严重程度没有显著关联.
结论:
- 尿路微生物群较少多样化,以减少乳酸菌和增加细菌多样性为特征,与混合性尿失禁妇女的尿失禁总和紧急性尿失禁发作增加有关.
- 这些发现表明,尿路微生物组的组成可能在混合性尿失禁的严重程度上起作用.
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