在equol生产状态和正常张力玻璃眼之间的关系
Noriko Himori1,2, Keiko Uchida1, Takahiro Ninomiya1
1Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
International ophthalmology
|June 27, 2024
概括
埃科尔 (Equol) 是一种大豆代谢物,可能有助于减缓正常张力玻璃眼的进展. 这表明饮食等生活方式因素可能会影响青光眼的发展.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 来自大豆异黄的Equol模仿雌激素,并受到饮食的影响.
- 已经注意到雌激素在玻璃眼瘤中的作用,这促使对equol的影响进行了调查.
- 饮食习惯,包括大豆消费,会影响肠道中的equol产量.
研究的目的:
- 在日本人群中调查equol生产状态和正常张力玻璃眼 (NTG) 之间的关系.
- 为了确定equol水平是否与青光眼的严重程度相关 (平均偏差-MD).
- 通过雌激素受体通路探索equol在玻璃眼中的潜在神经保护作用.
主要方法:
- 招募了68名NTG患者和31名对照 (绝经后妇女).
- 使用ELISA和从汉弗雷视野测试中计算的平均偏差 (MD) 来量化尿液等度.
- 使用斯皮尔曼等级相关性和曼-惠特尼U测试分析了MD和equol之间的关联;用于多变量分析的逻辑回归.
主要成果:
- 在NTG患者的equol水平和MD之间发现了显著的积极关联 (r=0.36,P<0.01).
- 与非生产者 (P=0.03) 相比,Equol生产者表现出明显较轻的青光眼 (较小的MD).
- 多变量分析确定了equol,circumpapillary视网膜神经纤维层厚度 (cpRNFLT) 和眼内压力 (IOP) 作为MD的独立贡献者.
结论:
- 埃科尔可以抑制NTG进展,可能是通过雌激素受体介导的神经保护.
- 这项研究支持这样一个假设:生活方式因素,包括饮食,可以影响青光眼.
- 需要进一步研究equol对绿眼的治疗潜力.
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