阿克里丁二-甲胺结合物:用于光学和光动力学治疗应用的分子内电子转移和单点氧气生成研究
Mohamed E El-Khouly1, Hassan A Khatab2, Ayamn A Abdel-Shafi3
1Nanoscience Program, Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Alexandria, Egypt. mohamed.elkhouly@ejust.edu.eg.
概括
结合phthalimide和acridine-1,8-diones的新混合分子显示了光学和医疗用途的潜力. 这些化合物表现出高效的电子转移和单点氧生成,用于光动力学疗法和向抗癌应用.
科学领域:
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
- 摄影化学的使用.
背景情况:
- 混合有机分子越来越多地被用于先进的光学和医疗应用.
- 聚胺和阿克里丁-1,8-二离子部分提供了独特的电子特性,适合功能性材料设计.
研究的目的:
- 为了合成和表征新型的混合合物phthalimide和acridine-1,8-diones.
- 研究光学特性,电子转移机制以及光动力学疗法 (PDT) 和向抗癌治疗中的潜在应用.
主要方法:
- 为了制备结合剂,采用了三步合成策略.
- 使用光谱技术 (吸收,光,与时间相关的单光子计数) 来研究光学特性.
- 进行了计算研究 (ab initio B3LYP/6-311G) 和分子对接.
主要成果:
- 合成的Acridine-1,8-dione-Phthalimide (AcrPhth) 合物吸收紫外线可见光,并由于分子内电子转移而表现出光灭.
- 通过光寿命测量和计算分析证实了快速电子转移过程.
- 化合物显示出作为单片氧生成光敏剂的潜力,并测量了单片量子产量.
- 分子对接表明AcrPhth 2对与癌症相关的基因具有很高的结合亲和力 (p53,TOP2B,p38,EGFR).
结论:
- 合成的AcrPhth合物具有有利的光学特性和高效的分子内电子转移.
- 这些混合分子作为PDT的光敏化剂和作为向抗癌剂具有前途.
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