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在瑞典的一项纵向研究中,表观遗传衰老和糖尿病之间的关联
Daniel Wikström Shemer1,2, Shayan Mostafaei1, Bowen Tang1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
表观遗传衰老生物标志物在2型糖尿病 (T2D) 患者中显示出差异. 然而,这些生物标志物在纵向研究中没有显著预测T2D风险,这表明需要T2D特定的表观遗传标志物.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2D) 与加速的生物衰老和与年龄有关的疾病风险增加有关.
- 表观遗传修饰,特别是DNA甲基化,被认为是生物衰老的可靠生物标志物.
研究的目的:
- 使用纵向数据调查各种表观遗传衰老生物标志物与发展T2D的风险之间的关联.
- 分析纵向生物标志物轨迹及其与糖尿病诊断时间的相关性.
主要方法:
- 利用了来自瑞典收养/双胞胎老龄化研究 (SATSA) 的纵向数据,其中有536名参与者.
- 采用了多种表观遗传生物标记的衰老,包括DNAm PAI-1,DNAmTL,DunedinPACE,PCHorvath1,PCHorvath2,PCHannum,PCPhenoAge和PCGrimAge.
- 应用了纵向分析,线性相关性和考克斯比例危险模型,对年龄,性别,BMI和吸烟等共变量进行调整.
主要成果:
- 纵向分析显示,与对照人群相比,T2D患者的DunedinPACE和DNAm PAI-1的轨迹不同,特别是在60-70岁左右.
- 这些生物标志物 (DunedinPACE,DNAm PAI-1) 在接近糖尿病发病时被发现更高.
- 考克斯的比例危险模型没有确定研究的表观遗传衰老生物标志物与T2D风险之间的显著关联.
结论:
- 虽然某些表观遗传衰老生物标志物在患有T2D的个体中显示出改变的模式,但它们可能不足以预测T2D风险.
- 强调开发专门针对T2D预测和建模的新型表观遗传生物标志物的潜在需要.
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