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Updated: Jun 22, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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一个基于库林5的复合体作为ORF9b稳定性在SARS-CoV-2复制中的必要调节器

Yuzheng Zhou1,2, Zongpeng Chen1, Sijie Liu1

  • 1Department of Cell Biology, School of Life Sciences, Central South University, 410013, Changsha, China.

Signal transduction and targeted therapy
|June 27, 2024
PubMed
概括

SARS-CoV-2 ORF9b 蛋白质通过无处化降解,由 CUL5-TOM70-HSP90α 复合体调节. 抑制HSP90α加速ORF9b的降解,减少病毒复制,并提供新的COVID-19治疗策略.

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