与肥胖相关的微生物组通过招募独特的中性粒细胞来煽动内脏脂肪组织炎症

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Dharti Shantaram¹, Rebecca Hoyd², Alecia M Blaszczak¹

¹Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH, 43210, USA.

Nature communications

|June 27, 2024

概括

肥胖与内脏脂肪中中性粒细胞增加有关,受肠道细菌和饮食的影响. 准这些中性粒细胞和相关细菌可能为与肥胖相关的炎症和疾病提供新的治疗方法.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
代谢障碍代谢障碍代谢障碍

背景情况:

中性粒细胞在慢性炎症和代谢障碍中发挥作用.
肥胖中的内脏脂肪组织 (VAT) 与中性粒细胞增加和独特的细菌群体有关.

研究的目的:

调查肥胖,肠道微生物群,饮食和中性粒细胞在增值税中积累之间的联系.
探索增值税中性粒细胞丰富的功能后果.

主要方法:

在肥胖和不肥胖的人群中,增值税中性粒细胞水平的比较.
在不同的饮食条件下,从肥胖和非肥胖的捐赠者那里获得的人类便的微生物缺乏的小鼠.
在VAT中分析免疫细胞群和基因表达.

主要成果:

肥胖与增值税中中性粒细胞数量较高有关.
高脂肪饮食与来自肥胖捐赠者的便相结合,在小鼠中诱导了增值税中性恋.
增值税中性细胞峰值与促进炎症的T细胞增加和调控性T细胞减少相关.
人类的VAT中性粒细胞表现出明显的基因表达特征.

结论:

供体微生物组和受体饮食是增值税中性恋的关键决定因素.
增值税中性粒细胞和相关细菌是肥胖相关并发症 (如胰岛素抵抗和结肠癌) 的潜在治疗点.

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