在扩展的杏仁体中,NPY介导的突触可塑性优先考虑饥饿期间的食
Stephan Dodt1,2, Noah V Widdershooven2, Marie-Luise Dreisow1,3
1Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Nature communications
|June 27, 2024
概括
来自饥饿神经元的神经Y (NPY) 适应大脑电路,促进禁食期间的食. 这涉及加强养电路和削弱焦虑电路,这种过程在缺乏NPY的小鼠中不存在.
科学领域:
- 神经科学是一个神经科学.
- 神经内分泌学神经内分泌学
- 行为神经科学 行为神经科学
背景情况:
- 饮食行为是由复杂的神经回路调节的.
- 下丘脑神经调节食,但它们在电路形成中的作用尚不清楚.
- 神经Y (NPY) 是一种参与养控制的氧化.
研究的目的:
- 为了研究NPY如何适应GABAergic输入到终端 (BNST) 的床核.
- 了解NPY在与食和禁食期间的焦虑相关的突触可塑性中的作用.
主要方法:
- 突触输入到BNST神经元的电生理学记录.
- 对NPY和Agouti相关 (AgRP) 表达神经元的基因操纵.
- 在小鼠中测量食和焦虑的行为测试.
主要成果:
- 禁食增加了AgRP神经元和BNST神经元之间的突触连接,促进了食.
- 禁食减少了从中央杏仁体 (CeA) 到BNST的GABAergic输入,减少了食抑制.
- 活化NPY表达AgRP神经元诱导这些突触变化,这些突触变化依赖于NPY.
- 缺乏NPY的小鼠表现出受损的食反应,并且未能在禁食期间减少焦虑.
结论:
- 阿古蒂相关 (AgRP) 神经元利用神经Y (NPY) 诱导BNST中的输入特定突触可塑性.
- 这种可塑性有助于在饥饿期间选择性地改变饥饿和焦虑信号.
- 在代谢压力下,NPY信号对于协调食行为和焦虑反应至关重要.
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