产后心脏逆转重塑的程度反映在尿液蛋白质组中
Ana F Ferreira1, Fábio Trindade1, Maria J Azevedo2,3,4,5
1Cardiovascular R&D Centre - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Scientific reports
|June 27, 2024
概括
泌尿蛋白质组分析确定了与怀孕后心脏逆转型 (RR) 相关的蛋白质,特别是在患有心血管风险因素的女性中. 这可以预测不完整的产后RR,并有助于管理长期的心血管健康.
科学领域:
- 心血管医学 心血管医学
- 蛋白质组学是指蛋白质组学
- 生殖健康 生殖健康
背景情况:
- 产后心脏逆转改造 (RR) 对于怀孕后心血管恢复至关重要.
- 患有心血管 (CV) 风险因素的孕妇长期面临心血管疾病风险的增加.
- 尿蛋白和产后RR之间的联系,特别是在高风险怀孕中,仍然不清楚.
研究的目的:
- 在有或没有心血管风险因素的孕妇中分析尿蛋白.
- 确定与产后左心室质量 (LVM) 回归相关的尿蛋白 (RR的替代品).
- 探索尿路蛋白质对不完整产后RR的预测潜力.
主要方法:
- 对32名健康和27名高风险孕妇进行前性队列研究.
- 胸前回声心电图,脉冲波速度和尿液收集在孕期第三季度和产后6个月.
- 射门HPLC-MS/MS用于尿路蛋白质组分析;通用线性混合效应模型用于关联分析.
主要成果:
- 产后动脉硬度增加,心血管风险因素在女性中显著增加.
- 心血管风险因素与较差的 LVM RR 有关.
- 确定了与LVM回归相关的17种蛋白质,与IGF运输,血小板活性和免疫反应功能相关.
- 尿液IGF-1度与较低的LVM回归相关.
结论:
- 尿蛋白质组分析可以识别与产后心脏逆向重塑相关的蛋白质.
- 特定的尿蛋白和IGF-1水平可以预测孕妇的不完全产后RR.
- 这些发现突出了尿路蛋白质组在监测产后妇女心血管恢复和风险分层方面的潜力.
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