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Updated: Jun 22, 2025

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

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编码为4-1BB的CAR通过基胺修饰酶A20的隔离导致细胞死亡

Zhangqi Dou1,2, Thomas Raphael Bonacci3, Peishun Shou1

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

Cellular & molecular immunology
|June 27, 2024
PubMed
概括

在CAR-T细胞中的4-1BB共刺激域通过隔离A20引起细胞死亡和聚合. 调节A20水平或4-1BB结合可以挽救这些效应并改善抗瘤活性.

关键词:
在 4-1BBBB 中.A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20 A20化学抗原受体 (CAR) -T细胞在 NF-κBB 中.尸体灭 (Necroptosis) 是一种死亡的过程.与TNF受体相关的因子 (TRAF)

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Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death13:54

Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death

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