使用多基因分数结合症状评分尺度来识别注意力缺陷/多动症障碍
André Høberg1, Berit Skretting Solberg2,3, Tor-Arne Hegvik4,5
1Department of Biomedicine, University of Bergen, Bergen, 5009, Norway. niz015@uib.no.
当与现有工具相结合时,ADHD多基因分数 (PGS) 为注意力缺陷/多动障碍 (ADHD) 提供了轻微的额外诊断信息. 然而,由于预测准确度略有提高,其目前的临床实用性有限.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 神经发育障碍 神经发育障碍
背景情况:
- 生物标志物可以提高注意力缺陷/多动障碍 (ADHD) 的诊断准确度.
- 反映遗传责任的ADHD多基因分数 (PGS) 是ADHD的潜在生物标志物.
研究的目的:
- 为了确定ADHD是否存在,PGS提供了超越标准ADHD评分尺度和家族病史的额外诊断信息.
- 评估ADHD PGS的增量预测值,以区分ADHD病例与对照病例.
主要方法:
- 计算了ADHD PGS对576名ADHD成年人和530名对照人群.
- 利用了包含ADHD PGS,Wender-Utah评分表 (WURS),成人ADHD自我报告表 (ASRS) 和家族史的后勤回归模型.
- 使用概率比测试和AICc.进行模型性能比较.
主要成果:
- ADHD PGS显著增加了ASRS (0.58pp),WURS (0.61pp),组合秤 (0.57pp) 和家族史 (1.40pp) 的解释变异.
- 通过概率比率测试和AICc证实了统计学意义,表明了小但重要的贡献.
结论:
- ADHD PGS提供了对现有的ADHD诊断辅助工具的补充信息.
- 目前,观察到的解释变异的增加太小,以至于ADHD PGS不能成为临床上有用的独立诊断工具.
- 未来的研究应该与非遗传因素一起探索ADHD PGS的实用性,并通过更多的遗传数据和先进的计算方法来完善其应用.
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