相关实验视频

Updated: Jun 22, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

17.2K

在Paenibacillus基因组中挖掘生物合成基因集群,以发现新型抗生素

Man Su Kim1,2, Da-Eun Jeong1, Jun-Pil Jang3

  • 1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

BMC microbiology
|June 27, 2024
PubMed
概括

这项研究揭示了Paenibacillus物种是新型抗生素的有希望的来源. 细胞因子基编辑器 (CBE) 介导的脱复制迅速发现了一种新的抗生素,布拉西丁,加速了药物发现.

关键词:
帕尼巴西勒斯 (Paenibacillus) 是一种抗生素脱复制的方法抗生素 抗生素是一种抗生素.生物合成基因集群生物合成基因集群细胞因子基编辑器 细胞因子基编辑器基因组开采是为了挖掘基因组.

更多相关视频

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

10.9K
Isolation of Soil Microorganisms Using iChip Technology05:33

Isolation of Soil Microorganisms Using iChip Technology

Published on: January 10, 2025

903

相关概念视频

Antibiotic Selection00:57

Antibiotic Selection

Overview
53.0K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.7K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
21.0K