在美国成年人中,与胆结石病相关的甘油三指数与胆结石病之间的关联
Chang Fu1, Xiaocong Li2, Yongxin Wang1
1Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Lipids in health and disease
|June 27, 2024
概括
胰岛素耐药性指标,如甘油三糖-体重指数 (TyG-BMI) 和甘油三糖-腰与身高比率 (TyG-WHtR),与胆结石疾病有关. TyG-WHtR显示出最强的关联,表明其对风险评估的潜力.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 心血管健康 心血管健康
- 胃肠病学 胃肠病学
背景情况:
- 胰岛素抵抗是代谢障碍的一个关键因素.
- 三甘油糖 (TyG) 指数及其与肥胖相关的变体 (TyG-BMI,TyG-WC,TyG-WHtR) 是胰岛素耐药性的新兴标志物.
- 这些新型胰岛素抵抗标志物与胆结石疾病之间的关系需要进一步研究.
研究的目的:
- 调查三糖糖 (TyG) 指数与肥胖指标 (TyG-BMI,TyG-WC,TyG-WHtR) 以及胆结石病的流行率之间的关联.
- 为了比较这些TyG相关指标的诊断性能,以确定胆结石疾病风险.
主要方法:
- 利用了来自2017-2020年国家健康和营养检查调查的3740名成年人的数据.
- 采用多变量逻辑回归模型,分析TyG-BMI,TyG-WC和TyG-WHtR作为连续和分类变量.
- 应用了限制立方线和子组分析,以探索剂量-反应关系并确认发现.
主要成果:
- 当分析为连续变量时,在TyG-BMI,TyG-WC,TyG-WHtR和胆结石疾病之间发现了显著的正相关性.
- 每增加10个单位的赔率比为TyG-BMI的1.063,TyG-WC的1.026和每增加1个单位的TyG-WHtR的1.483.
- 当分类为四分位数时,所有三个指数都与胆结石疾病保持了统计学上显著的关联,TyG-WHtR显示出最高的AUC (0.667).
结论:
- 与TyG相关的指数,包括TyG-BMI,TyG-WC和TyG-WHtR,与增加胆结石疾病风险有显著的相关性.
- 在评估的指数中,TyG-WHtR显示了胆结石疾病的最强的预测能力.
- 这些发现凸显了TyG相关指数在评估胆结石疾病风险,特别是TyG-WHtR中的潜在实用性.
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