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基于酸的新型深溶剂作为一种多功能催化剂,用于合成pyrimido[4,5-d]pyrimidines和pyrano[3,2-c]chromenes

Arezo Monem¹, Davood Habibi², Abdolhamid Alizadeh³

¹Department of Organic Chemistry and Petroleum Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran.

|June 27, 2024

概括

一种由甲基三-酸和酸合成的新型深度环氧溶剂 (DES) 作为一种高效的催化剂. 这种绿色化学方法在温和的无溶剂条件下促进复杂的异环化合物的合成.

科学领域:

绿色化学绿色化学
催化剂是一种催化剂.
材料科学材料科学材料科学

背景情况:

深度浸泡溶剂 (DES) 正在成为传统溶剂的可持续替代品.
酸催化剂在各种有机合成反应中起着至关重要的作用.
开发高效和可回收的催化系统对于绿色化学至关重要.

研究的目的:

从甲基三基化物 (MTPPBr) 和酸 (PHTH) 合成和描述一种新型的DES.
评估合成的DES在pyrimido[4,5-d]pyrimidines和pyrano[3,2-c]chromes的合成中的催化活性.
为了证明在无溶剂条件下使用这种DES作为催化剂的优点.

主要方法:

合成DES使用eutectic点相图来确定最佳的摩尔比率 (1:1 MTPPBr:PHTH).
使用FT-IR,TGA/DTA,密度计,欧特克点分析和NMR光谱学对DES的表征.
应用DES作为酸催化剂在目标异环化合物的无溶剂合成中.

主要成果:

成功合成和描述了一种新的MTPPBr-PHTH-DES.
在合成pyrimido[4,5-d]pyrimidines和pyrano[3,2-c]chromes时,DES表现出高的催化效率.
催化过程表现出短的反应时间,低温,易于分离和可回收的DES催化剂.

结论:

MTPPBr-PHTH-DES是一种高效和可回收的绿色催化剂.
这种方法为合成有价值的异环化合物提供了可持续和高效的途径.
无溶剂条件和催化剂可重复使用性突出显示了这种方法对环境的好处.

关键词:

在 DES DES 中,您可以使用甲基三四化物化物甲酸是甲酸中的一种.皮拉诺 - 克罗米内斯.皮里米多皮里米丁类药物.

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