对于兴奋剂药物来说,大脑均的稳定性是相同的
Grayce Behnke1, Teresa R Gray1, Crystal Arndt1
1Forensic Toxicology Laboratory, Harris County Institute of Forensic Sciences, 1861 Old Spanish Trail, Houston, TX 77954, United States.
这项研究表明,兴奋剂药物在冷的大脑同质物中稳定长达90天,支持它们在毒理学测试中的使用. 其他储存条件显示这些重要的法医分析物的稳定性是可变的.
科学领域:
- 法医毒理学 法医毒理学
- 神经科学是一个神经科学.
- 分析化学 分析化学
背景情况:
- 由于大脑的保护性质和较低的代谢活动,大脑是毒理学的宝贵标本.
- 有限的数据存在于用于毒理学分析的准备的大脑同质物中兴奋剂药物的稳定性.
研究的目的:
- 评估十种兴奋剂药物在各种储存条件下的准备的大脑同质物中的稳定性.
- 为了确定化对大脑组织中药物稳定性的影响.
主要方法:
- 用兴奋剂药物 (安非他林,可卡因,甲基安非他林等) 强化的准备的大脑同质物. 在500 ng/mL时.
- 在室温,冷藏或冷保存的样品最长可保存90天.
- 使用气色谱-质谱分析药物稳定性,评估分析物/内部标准反应比.
主要成果:
- 所有经过测试的兴奋剂药物在冷,含有或不含化的情况下储存时最多稳定90天.
- 在室温和冷藏下储存的分析物中观察到可变稳定性.
- 化没有显著影响可卡因或其他兴奋剂在冷条件下的稳定性.
结论:
- 冷的大脑同质物适用于高达90天的兴奋剂药物的毒理分析.
- 储存条件显著影响兴奋剂药物在脑组织中的稳定性.
- 这些发现支持在法医毒理学中使用大脑组织来检测兴奋剂药物.
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