相关实验视频

Updated: Jun 22, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

炎症性皮肤疾病和乳腺癌之间的因果关系:双向的门德尔随机化研究

Yiling Yang¹, Juhua Zhao¹

¹Department of Dermatology, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

|June 28, 2024

概括

乳腺癌 (BC) 与的风险增加和阿托皮性皮肤炎 (AD) 的风险降低有关. 这项研究使用了门德尔的随机化来调查欧洲人群中炎症性皮肤疾病和BC之间的因果关系.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
遗传流行病学遗传流行病学

背景情况:

炎症性皮肤疾病和乳腺癌 (BC) 之间的关系正在调查中,但因果关系尚不清楚.
了解这些关联对于全面的患者护理和风险评估至关重要.

研究的目的:

使用双向门德尔随机化 (MR) 方法调查特定炎症性皮肤疾病和乳腺癌 (BC) 之间的潜在因果关系.
要区分BC影响皮肤状况和反之.

主要方法:

进行了一项双向的双样本孟德尔随机化 (MR) 研究.
与,亚托皮性皮肤炎 (AD),牛皮,疹和粉红疹相关的遗传变异被分析与乳腺癌风险相关.
采用逆方差加权 (IVW),加权中位数 (WME) 和MR-Egger方法,并对变性和异质性进行敏感性分析.

主要成果:

乳腺癌 (BC) 与的风险增加有关 (OR=1.063,p=0.016).
乳腺癌患者 (OR=0.941,p=0.047) 观察到阿托皮性皮肤炎 (AD) 的风险降低.
在BC和牛皮,疹或疹之间没有发现显著的因果关系,BC也没有影响炎症性皮肤疾病的发病率.

结论:

这项研究表明,乳腺癌可能会增加的发病率,这可能是潜在的因果关系.
相反,乳腺癌似乎与欧洲人群中的亚托皮炎发病率降低有关.
这些发现突显了全身性疾病和皮肤病症之间的复杂相互作用.

关键词:

门德尔的随机化一般性 (acne vulgaris) 是一种亚托邦性皮肤炎的发生.乳腺新生体乳腺瘤牛皮一般的牛皮.罗萨西亚 (Rosacea) 是一种红色的疾病.皮肤疾病皮肤疾病疹病是一种疹病.

更多相关视频

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

相关概念视频

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...