在老年住院患者中使用较低剂量的环二
Katherine G Coli1, Jaylan M Yuksel2, Kenneth L McCall3
11 Upstate University Hospital, Pharmacy Department, Syracuse, New York.
The Senior care pharmacist
|June 28, 2024
概括
在老年住院患者中使用较低剂量的环素可以减少住院时间 (LOS) 和注射精神药物的需要. 这项研究比较了5毫克与10毫克的剂量,发现较低剂量有好处.
科学领域:
- 老年医学 老年医学
- 临床药理学 临床药理学
- 医院管理局 医院管理局
背景情况:
- 抗胆固醇药物,如环素,对老年住院患者构成风险,可能增加并发症和停留时间 (LOS).
- 高剂量的环二与不良事件有关,例如老年患者的精神状态变化和跌倒.
研究的目的:
- 评估较低剂量的环素 (5毫克) 与较高剂量 (10毫克) 相比,是否会影响65岁及以上患者的医院LOS.
- 评估循环司剂量对30天再接收率的影响以及注射精神药物的需求.
主要方法:
- 超过2.5年的65岁以上住院患者的回顾性队列分析,比较了5毫克和10毫克环二组之间的结果.
- 主要结局:医院LOS (多变量线性回归). 二次结局:30天再接收率 (逻辑回归) 和注射抗精神病药物/二类药物的使用.
- 分分析检查了老年人处方环境 (GEM-CON) 对剂量选择的影响.
主要成果:
- 接受更高剂量的环素的患者在医院调整后的LOS显著更长 (32.7%的增加).
- 使用较高剂量的环素与增加注射抗精神病药物和二zepines的需求显著相关.
- 在循环司剂量和30天再入院率之间没有发现显著的关联.
结论:
- 在老年住院患者中,低剂量环素 (5毫克) 与减少医院LOS有关.
- 使用较低剂量的环素降低了在这个人群中注射抗精神病药物和二氨酸的需求.
- 实施GEM-CON成功地增加了推的较低环素剂量的使用.
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