基于超抗原的高亲和性三功能免疫细胞激活剂协同激活NK和T细胞激活以抑制瘤
Yao-An Yu1,2, Wan-Ju Lien1, Wen-Ching Lin1
1Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 28, 2024
概括
一种新型的多价值免疫细胞吸引剂 (ICE) 增强了NK和T细胞对固体瘤的招募,改善了瘤抑制. 这种基于超抗原的方法为高级癌症免疫疗法提供了新的设计原则.
科学领域:
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
- 在瘤学瘤学.
背景情况:
- 目前的免疫细胞参与者 (ICE) 在融合蛋白设计方面面临局限性,阻碍了免疫细胞对固体瘤的有效招募.
- 开发克服这些局限性的策略对于推进癌症免疫治疗至关重要.
研究的目的:
- 设计一种基于超抗原的高亲和度多价值ICE,同时激活和招募自然杀手 (NK) 和T细胞.
- 增强免疫细胞透和固体瘤中的抗瘤活性.
主要方法:
- 利用基于酵母库的定向进化来识别具有对人类T细胞和NK细胞免疫受体增强结合亲和力的超抗原变体.
- 开发了一种三功能酵母显示增强的多价值免疫细胞吸引剂 (STYMIE),结合了高 afinity 超抗原,用于瘤向的纳米体,用于免疫刺激的Neo-2/15细胞因子,以及用于延长循环的Fc域.
主要成果:
- 确定了具有显著改善结合亲和力和免疫刺激活动的超抗原变体.
- 证明,静脉注射STYMIE有效地增强了NK和T细胞在固体瘤中的招募.
- 在STYMIE治疗后的多个固体瘤模型中观察到增强的瘤抑制.
结论:
- 开发的基于超抗原的多价值ICE (STYMIE) 显示出通过招募和激活免疫细胞来增强抗瘤免疫力的巨大潜力.
- 这项研究为创建下一代多功能ICE用于癌症治疗提供了有价值的设计原则.
更多相关视频
相关概念视频
Tumor Immunotherapy
510
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
510
Cytotoxic T Cells-mediated Immune Response
888
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
888
T Cell Activation and Clonal Selection
699
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
699
Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K


