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卡梅利祖马布诱导的过敏反应:一个病例报告和文献综述
Jiarui Hu1, Jieting Fan1, Shaobo Qu1
1Department of Traditional Chinese Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Journal of chemotherapy (Florence, Italy)
|June 28, 2024
概括
本案例研究报告了第一例由免疫检查点抑制剂camrelizumab引起的过敏反应,该病例发生在患有晚期状细胞癌的患者身上. 这种反应发生在第八次卡梅利祖马布 (camrelizumab) 给药后,凸显了需要保持警的必要性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 卡姆雷利祖马布是一种免疫检查点抑制剂,用于癌症治疗.
- 与免疫相关的不良事件 (irAEs) 与检查点抑制剂是常见的.
- 对camrelizumab的过敏反应很少发生,但可能严重.
研究的目的:
- 报告第一例对camrelizumab的过敏反应病例.
- 描述卡梅利祖马布诱导的过敏反应的临床表现和管理.
- 强调在接受卡姆雷利祖马布治疗的患者中识别和管理过敏反应的重要性.
主要方法:
- 一个58岁的男性患者的病例报告,患有口腔底部晚期状细胞癌.
- 患者接受了卡姆雷利祖马布与化疗 (与白结合的帕克利塔塞尔和西斯) 结合治疗.
- 详细描述过敏反应的发作,症状和立即管理.
主要成果:
- 患者在第八次camrelizumab剂量后30分钟经历过敏反应.
- 症状包括出汗,白,湿,蓝色,低血压和缺氧.
- 用甲基prednisolone和多巴胺迅速治疗导致了快速恢复.
结论:
- 过敏反应,虽然很少见,可以由camrelizumab诱导.
- 警和及时管理对于在卡梅利祖马布治疗期间出现过敏反应的患者至关重要.
- 这一案例强调了对免疫检查点抑制剂的严重过敏反应需要提高认识.
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