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Updated: May 7, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

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多价值抑制Aspergillus烟草KDNase的多价值抑制

Mathieu Scalabrini1, Denis Loquet1, Camille Rochard2

  • 1Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France. sebastien.gouin@univ-nantes.fr.

Organic & biomolecular chemistry
|June 28, 2024
PubMed
概括

研究人员使用多价值策略开发了Aspergillus fumigatus KDNase (AfKDNAse) 的强效抑制剂. 聚-KDN化合物显著降低了真菌纤维化,显示出作为抗病毒因子的前景.

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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