中度和重度大动脉狭窄症的并发症和症状状态:一个多中心临床队列研究
David Playford1,2, Nisha Schwarz1, Enayet Chowdhury1
1Advara Heart Care, Leabrook, Adelaide, Australia.
呼吸障碍在中度和重度的大动脉狭窄 (AS) 中很常见,与并发症有关,但与心脏损伤无关. 基于症状的管理可能需要重新评估AS患者.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 临床研究 临床研究
背景情况:
- 严重的大动脉狭窄 (AS) 的症状对于指导患者管理至关重要.
- 了解中度和重度AS的症状模式对于最佳护理至关重要.
- 伴随性疾病和心脏损伤是影响AS进展和结果的关键因素.
研究的目的:
- 调查中度和重度大动脉狭窄症 (AS) 患者的患病率和症状模式.
- 分析AS中症状,并发症和心脏损伤程度之间的关联.
- 评估呼吸困难,胸痛和昏迷与AS严重程度相关的作用.
主要方法:
- 追溯分析了来自330,940名中度或重度AS患者的846,198次心声回声图.
- 使用自然语言处理 (NLP) 来从临床笔记中提取症状和并发症数据.
- 排除先前进行过大动脉置换的患者,以专注于本源膜疾病.
主要成果:
- 症状在41.3%的中度AS患者和47.7%的严重AS患者中普遍存在.
- 在这两组中,高血压和心房等并发症是常见的.
- 呼吸障碍与严重的AS有显著的关联,而心痛和昏迷在严重程度组之间是相似的. 心脏损伤与症状存在没有相关性,但与AS严重程度有关.
结论:
- 呼吸不良是中度和重度大动脉狭窄 (AS) 的常见症状,与并发症相关.
- 心脏损伤的程度似乎与AS的症状发生无关.
- 根据这些发现,目前针对AS的症状指导管理策略可能需要重新评估.
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