生物标志物和冠状动脉微血管功能障碍在患有心痛和没有阻塞性冠状动脉疾病的妇女中
Eva Prescott1, Kira Bang Bove1, Daria Frestad Bechsgaard1
1Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.
JACC. Advances
|June 28, 2024
概括
蛋白质生物标志物如宁和BNP可以帮助识别冠状动脉微血管功能障碍 (CMD),这是没有动脉阻塞的胸痛的原因. 添加这些生物标志物提高了诊断模型的准确性,尽管预测仍然适度.
科学领域:
- 心血管医学 心血管医学
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 是非阻塞性冠状动脉患者心肌缺血的一个重要原因.
- 诊断CMD往往依赖于侵入性或复杂的成像技术.
研究的目的:
- 为了识别蛋白质生物标记符号,用于诊断CMD.
- 在临床队列中评估这些生物标志物的预测性能.
主要方法:
- 使用近距离延伸测定在1471名患有胸痛的女性中量化了184种心血管蛋白质.
- 使用冠状动脉流速储备 (CFVR) 通过横胸回声多普勒评估CMD.
- 采用相关性分析,主要组件分析和机器学习来识别生物标志物和预测模型开发.
主要成果:
- 61种与CFVR相关的蛋白质,其中素 (REN),GDF-15,BNP,NT-proBNP和ADM显示最强的关联.
- 结合生物标志物的机器学习模型实现了0.66的ROC-AUC,这比单独的临床数据 (ROC-AUC0.61) 更好.
- 关键的预测生物标志物包括REN,BNP,NT-proBNP,GDF-15和ADM.
结论:
- 冠状动脉疾病与炎症 (IL-6),血压调节 (REN,ADM) 和心脏重塑 (BNP/NT-proBNP) 途径有关.
- 生物标志物的纳入增强了CMD预测模型,尽管整体预测能力仍然适度.
- 蛋白质生物标志物在临床实践中为改善CMD评估提供了潜力.
更多相关视频
08:35Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
2.4K
10:28Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
4.9K
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
136
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
136
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
76
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
76
01:16Antianginal Drugs: Nitrates and β-Blockers
571
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
571