怀孕期间心脏生物标志物的利用和解释:JACC:进展 专家小组
Amy A Sarma1,2, Niti R Aggarwal3, Joan E Briller4
1Massachusetts General Hospital, Boston, Massachusetts, USA.
JACC. Advances
|June 28, 2024
概括
心脏生物标志物,如尿酸和素,在没有并发症的怀孕中通常很低. 产后可能会出现升高的水平,但需要对心血管疾病进行调查.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床生物化学 临床生物化学
背景情况:
- 心脏生物标志物对于诊断非怀孕个体的心血管 (CV) 病理至关重要.
- 怀孕期间心脏生物标志物的解释不太清楚,尽管心脏功能障碍和潜在的心血管并发症的症状重叠.
- 本综述讨论了怀孕期间心脏生物标志物的当前知识和临床应用.
研究的目的:
- 总结有关怀孕期间心脏生物标志物使用的当前知识.
- 为临床实践提供基于证据的建议,关于怀孕个体心脏生物标志物.
- 澄清心脏生物标志物在怀孕期间和之后诊断心脏病的作用.
主要方法:
- 在怀孕期间对心脏生物标志物 (尿素,素) 的研究的文献综述.
- 在没有并发症的怀孕,先前存在的/怀疑的心血管疾病和分娩后的生物标志物行为分析.
- 综合证据以指导临床解释和应用.
主要成果:
- 在没有并发症的怀孕中,尿素和热波水平应保持低.
- 这些生物标志物在怀孕的孕妇中保持了对心血管疾病的负预测值,这些孕妇具有先前存在的或可疑的疾病.
- 产后 natriuretic和热波的升高可能会发生,需要进一步调查心血管病理.
结论:
- 在没有并发症的怀孕中不建议定期测量心脏生物标志物.
- 心脏生物标志物是评估心血管疾病风险和诊断在孕妇群体有必要时有价值的工具.
- 心脏生物标志物升高,特别是产后,需要进行彻底的评估,以排除潜在的心血管问题.
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