与心肌纤维化相关的生殖因素:MESA (动脉样硬化多民族研究)
Omar Chehab1, Ralph Zeitoun1, Vinithra Varadarajan1
1Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
JACC. Advances
|June 28, 2024
概括
在女性中,无胎儿和无妊娠与间歇性心肌纤维化增加有关. 激素替代疗法 (HRT) 的使用与女性心肌痕风险降低有关.
科学领域:
- 心血管疾病研究研究
- 生殖健康研究 生殖健康研究
- 医学成像分析 医学成像分析
背景情况:
- 生殖因素越来越多地被认为是女性心力衰竭的危险因素,心力衰竭的风险因素是保持喷射分数 (HFpEF).
- 连接生殖史与HFpEF的潜在病理机制在很大程度上仍未定义.
- 亚临床心肌纤维化是大量HFpEF患者的重大病理发现.
研究的目的:
- 研究关键生殖因素与心肌纤维化之间的关联.
- 为了确定平价,妊娠史,更年期年龄和激素替代疗法 (HRT) 使用与心磁共振成像 (CMR) 测量间歇性心肌纤维化 (IMF) 和心肌痕之间的关系.
主要方法:
- 利用了多民族动脉样硬化研究 (MESA) 中596名女性参与者的数据,包括完整的平价信息和CMR扫描.
- 评估IMF使用细胞外体积 (ECV) 和本地T1映射,以及通过CMR晚期加多增强的心肌痕.
- 采用多变量回归模型来分析平价状态,无妊娠,绝经年龄和HRT使用与IMF和痕指标之间的关联.
主要成果:
- 与1-2个活产的女性相比,零平价的女性表现出显著更高的ECV和本地T1值,表明更大的IMF.
- 与怀孕史相比,零怀孕史也与IMF标志物 (ECV和原生T1) 的增加有关.
- 在更年期的年龄和IMF之间没有发现任何显著的关联.
- 激素替代疗法 (HRT) 的使用独立地与心肌痕的可能性较低有关 (几率比:0.20).
结论:
- 无胎儿和无怀孕与女性间歇性心肌纤维化增加有关,根据CMR检测.
- 女性使用激素替代疗法 (HRT) 与心肌痕的流行率降低有关.
- 这些发现突显了生殖史在心脏结构中的作用,并可能为女性心血管疾病的风险分层提供信息.
更多相关视频
09:16Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
7.3K
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
8.5K
相关概念视频
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
