微封装,物理化学表征,以及 Holothuria atra 的抗氧化,抗菌和抗质活性微囊微囊
Prawesty Diah Utami1, Herin Setianingsih2, Dewi Ratih Tirto Sari3
1Parasitology Department, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.
Scientifica
|June 28, 2024
概括
微封装Holothuria atra增强了它的特性. CHI90配方表现出强大的抗菌活性,而CHI120表现出强大的抗氧化作用,其中特定的化合物表现出抗质活性.
科学领域:
- 海洋天然产品 海洋天然产品
- 生物材料科学是生物材料的科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 海洋无脊椎动物Holothuria atra中含有生物活性化合物.
- 微封装是一种提高生物活性化合物的稳定性和输送的技术.
- 酸 (CHI) 和三聚酸 (Na-TPP) 常用于微封装.
研究的目的:
- 为了设计和描述 Holothuria atra 提取物的微囊.
- 评估微囊的抗氧化,抗菌和抗质活动.
- 为了确定最佳的微封装条件.
主要方法:
- 对H. atra的乙醇提取物进行了微封装,用CHI和Na-TPP进行了微封装,使用不同的时间 (60,90,120分钟).
- 使用扫描电子显微镜 (SEM) 和富里埃变换红外光谱 (FTIR) 分析了物理化学性质.
- 通过DPPH测定评估抗氧化活性,通过S. aureus和E. coli对抗抗菌活性,通过in silico分子对接评估抗氧化活性.
主要成果:
- 微囊表现出不同的尺寸和形状,基于时间.
- CHI90微囊显示出针对大肠杆菌和金黄色杆菌的显著抗菌活性.
- CHI120微囊显示了高的抗氧化活性.
- 化B和乙化B显示出对Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) 的抗等离子体活性.
结论:
- CHI90微囊配方是最佳的抗菌应用.
- CHI120微囊配方适用于抗氧化剂应用.
- 海洋衍生的化物化物B和乙化物B显示出对抗等离子体的药物开发的前景.
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