应用新的方法方法来评估下一代烟草和尼古丁产品
David Thorne1, Damian McHugh2, Liam Simms3
1BAT (Investments) Ltd., Southampton, Hampshire, United Kingdom.
Frontiers in toxicology
|June 28, 2024
概括
新方法方法 (NAM) 为新型消费产品,包括下一代尼古丁产品 (NGP) 提供先进的体外和内毒理学测试. 这些方法减少了对动物试验的依赖,并改善了与人类相关的安全评估.
科学领域:
- 毒理学 毒理学 毒理学
- 计算生物学 计算生物学
- 在体外检测中进行检测.
背景情况:
- 传统的毒理学依赖于过时的,高剂量的动物试验,对人类的相关性有限.
- 分子和细胞生物学方面的进步使产品安全评估的新方法方法 (NAMs) 成为可能.
- 下一代尼古丁产品 (NGP) 需要严格的科学评估才能获得监管部门的批准.
研究的目的:
- 探索NAM的应用,以评估下一代尼古丁产品 (NGP) 的安全性.
- 突出在NGP测试中实施NAM的关键考虑因素.
- 讨论方法标准化和监管接受的重要性.
主要方法:
- 使用in silico计算方法和人体体体外组织系统.
- 使用中等和高通量体外细胞查.
- 测试物品的特征和用于危险识别的选.
主要成果:
- NAM提供可靠,与人类相关的数据,用于评估新型消费产品.
- 在过去的十年里,体外工具和能力有了显著的进步.
- 正在制定框架和路线图,以支持NAM的验证和接受.
结论:
- 与传统香烟相比,NAM可以补充NGP的安全评估,降低风险.
- 适当的体外模型,选方法和测试物品的表征对于NGP评估至关重要.
- 行业合作和方法标准化对于NGP测试中NAM的监管接受至关重要.
关键词:
不良结果路径 (AOP)气道模型的气道模型.剂量测量方法 剂量测量方法高内容分析 - 高内容分析人类3D组织.新方法方法论 (NAM)下一代产品 (NGP) 是指新一代产品.在芯片上的器官 (OoC)更多相关视频
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