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质子抑制剂的使用与肝脏肥胖症的增加有关
Hongsheng Yu1,2, Mingkai Li1,2, Bilan Yang1,2
1Department of Gastroenterology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China.
质子抑制剂 (PPI) 的使用与美国成年人患肝硬化或脂肪肝疾病的风险更高有关. 长时间的PPI治疗可能会随着时间的推移增加这种风险,因此需要进一步调查长期并发症.
科学领域:
- 胃肠病学和肝病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 质子抑制剂 (PPI) 广泛用于与酸有关的胃肠道疾病.
- 人们担心PPI治疗的潜在长期不良影响.
- PPI使用与肝脏疾病 (如肝硬化症) 之间的关联需要进一步调查.
研究的目的:
- 调查PPI治疗与肝硬化和肝纤维化发病率之间的关联.
- 检查长期使用PPI对患肝硬化风险的影响.
- 分析美国门诊患者群体中的这些关联.
主要方法:
- 利用了来自美国国家健康和营养检查调查 (2017-2020) 的7395名美国成年人 (年龄≥20岁) 的数据.
- 使用振动控制的短暂弹性图形 (VCTE) 评估肝硬化和肝纤维化.
- 采用多变量回归分析和灵敏度分析,使用各种肝硬化症定义.
主要成果:
- 质子抑制剂 (PPI) 的使用与肝脏肥胖症显著相关 (OR,1.25;95% CI,1.02-1.53).
- 长期使用PPI显示,随着时间的推移,患肝硬化症的风险增加 (P=0.006).
- 在不同定义的肝脂肪症中发现了一致的关联,包括非酒精性脂肪性肝病和与代谢功能障碍相关的脂肪性肝病.
结论:
- 质子抑制剂 (PPI) 治疗与美国成年人的肝脏肥胖症有关.
- 通过VCTE测量PPI使用和肝硬度之间没有发现显著的关联.
- 这些发现突出了PPI和脂肪肝疾病之间的潜在联系,需要进一步研究长期安全性.
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