对内质网膜应激和动脉样硬化的一种图书统计分析
Xinyu Huang1, Feng Jiang2, Yongbo Ma1
1Shandong University of Traditional Chinese Medicine, Shandon, China.
Frontiers in physiology
|June 28, 2024
概括
细胞内膜网膜应激 (ERS) 是动脉样硬化 (AS) 发展的一个关键因素. 这种图书统计分析绘制了研究格局,揭示了ERS-AS的连接,机制和新出现的热点,如血管化.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 生物医学信息学 生物医学信息学
背景情况:
- 动脉样硬化 (AS) 病变发生涉及多种机制,其中内质网膜应激 (ERS) 是一个重要的,但尚未研究的因素.
- 对ERS和AS之间的关系缺乏全面的文献计量分析,这阻碍了对研究环境的清晰理解.
研究的目的:
- 对有关内质网膜应激和动脉样硬化的出版物进行文献分析.
- 为了绘制空间时间分布,关键贡献者和ERS-AS领域的研究趋势.
- 确定当前的研究热点和新兴的边界在ERS-AS研究.
主要方法:
- 来自Web of Science核心集合的1035个记录的图书统计分析.
- 使用CiteSpace,VOSviewer和R软件包"bibliometric"进行数据分析和可视化.
- 分析出版物数据,包括国家,作者,机构,期刊,参考文献和关键词.
主要成果:
- 在过去的二十年里,ERS和AS领域的逐步发展和稳定.
- 关键的研究领域包括ERS在AS相关细胞中的作用,其促进AS,相关疾病和细胞因子的机制.
- 新兴的研究前沿和热点包括血管化,内皮功能障碍,NLRP3炎症体和心力衰竭.
结论:
- 本文献计量研究提供了ERS-AS研究领域的可视化概述.
- 它强调了既有和新兴的研究主题,为未来的调查提供了洞察力.
- 这些发现旨在指导未来关于动脉样硬化的ERS的研究和临床策略.
相关概念视频
Role of ER in the Secretory Pathway
5.4K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
5.4K
Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
Smooth Endoplasmic Reticulum
5.7K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
5.7K
The Unfolded Protein Response
4.5K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
4.5K
Protein Folding Quality Check in the RER
3.7K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
3.7K
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30


