相关实验视频

Updated: Jun 22, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

英国生物库参与者的睡眠模式,遗传易感性和腹腔大动脉动脉瘤:大型队列研究

Dongliang Zhu¹, Xiaoguang Li², Qiuhong Man³

¹Department of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.

|June 28, 2024

概括

健康的睡眠模式降低了腹腔大动脉动脉瘤 (AAA) 的风险,即使在具有高遗传易感性的个体中也是如此. 这一发现强调了睡眠质量对心血管健康的重要性.

科学领域:

心血管科学心血管科学
睡眠医学睡眠医学
遗传学遗传学是一个

背景情况:

腹腔大动脉动脉瘤 (AAA) 是心血管死亡的一个重要因素.
了解AAA的风险因素对于预防和管理至关重要.

研究的目的:

研究睡眠模式和对腹腔大动脉动脉瘤 (AAA) 的遗传倾向之间的关系.
为了确定健康的睡眠习惯是否可以减轻AAA风险,特别是在遗传敏感的个体中.

主要方法:

利用了来自344,855名在基线没有AAA的参与者的英国生物库数据.
评估睡眠模式 (时间型,持续时间,失眠,打,白天嗜睡) 和遗传风险 (多基因风险评分).
采用Cox比例危险回归来分析睡眠,遗传和AAA发病率之间的关联,平均时间为12.59年.

主要成果:

总共有1,622起事件AAA病例被确定.
每增加1个健康睡眠得分的1个点都与AAA风险降低9%有关 (HR:0.91).
睡眠不良模式显著增加了AAA风险 (HR:1.40),睡眠不良和高遗传风险 (2.5倍增加) 的人群中观察到的风险最高.

结论:

健康的睡眠模式与腹腔大动脉动脉瘤 (AAA) 的发病率较低有关.
健康睡眠的保护作用在所有AAA遗传风险水平上都被观察到.
促进健康睡眠可能是一个可行的策略来减少AAA风险,补充遗传风险评估.

关键词:

腹部大动脉动脉瘤腹部大动脉动脉瘤遗传风险遗传风险遗传风险睡眠模式睡眠模式睡眠评分睡眠评分睡眠评分

更多相关视频

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Factors affecting Blood pressure

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

Pedigree Analysis

Pedigree Analysis