一种转录基因生物标志物预测了在治疗耐药结核病期间与线索利德相关的神经病变
Nika Zielinski1,2,3, Dragos Baiceanu4,5, Antonela Dragomir4,5,6
1Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.
Pathogens & immunity
|June 28, 2024
概括
一种新的生物标志物Suprabasin (SBSN) 可能预测在多药耐药结核病中,因linezolid治疗而导致的神经损伤. 这一发现可能有助于在治疗开始之前预防不可逆转的神经病变.
科学领域:
- 药物基因组学 药物基因组学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 针对多药耐药/瑞皮辛耐药结核病 (MDR/RR-TB) 的莱涅佐利德治疗经常导致神经病性不良事件.
- 一些与linezolid相关的神经病变可能是不可逆转的,需要预测性生物标志物.
研究的目的:
- 在MDR/RR-TB治疗之前,识别和验证基于宿主RNA的生物标志物,预测线索利德相关的神经病变.
- 为了确定与线化物相关的神经病变相关的基因和途径.
主要方法:
- 在三个德国队列中,预期招募成人患者开始使用linezolid治疗MDR/RR-TB.
- 全血RNA转录分析和临床数据收集.
- 使用随机森林算法识别生物标志物,并在第四个罗马尼亚队列中进行验证.
主要成果:
- 46.2%的患者在线索利德治疗期间出现了外周和/或视神经病变.
- 超巴辛 (SBSN) 表达被确定为一种潜在的预测生物标志物.
- 生物标志物算法在验证队列中显示了等级≥3神经病变的中度预测性能 (AUC0.63).
结论:
- 在MDR/RR-TB治疗开始之前,已经确定并初步验证了一种潜在的临床生物标志物 (SBSN),用于预测线索利德相关的神经病变.
- 需要对更大,更多样化的群体进行进一步的研究,以确认SBSN生物标志物的实用性.
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