乙素和2型炎症媒介体与骨质炎的相关性 在慢性鼻炎中与鼻息肉
Zhidi Zhang1, Qiang Zuo1, Yali Du1
1Department, Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Journal of inflammation research
|June 28, 2024
概括
患有鼻息肉的慢性鼻炎 (CRSwNP) 的骨炎与严重程度的增加有关. 高水平的IL-13,周骨蛋白和埃索诺菲尔是CRSwNP患者骨炎发展的关键风险因素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 骨质炎经常在患有鼻息肉的慢性鼻炎 (CRSwNP) 中观察到,有助于疾病的折射性和复发.
- 在CRSwNP中骨质炎的确切病理生理机制尚不完全理解.
研究的目的:
- 在被诊断患有CRSwNP的患者中,研究乙氨基酸,2型炎症媒介和骨质炎之间的关联.
- 在CRSwNP的背景下,确定有助于骨炎形成的潜在风险因素.
主要方法:
- 一项回顾性研究涉及125名CRSwNP患者,根据CT扫描分为骨炎和非骨炎组.
- 临床数据,2型炎症调解剂 (包括IL-13) 和异osinophil数量之间的组之间的比较.
- 评估这些因素与全球骨炎评分表 (GOSS) 之间的相关性.
主要成果:
- 骨炎组表现出更高的喘患病率,SNOT-22,LUND-MAKAY和LUND-KEDENY分数. 这一点数显示出骨炎组的喘患病率更高.
- 在骨质炎组中发现IL-13,骨周蛋白质和组织埃索诺菲尔水平显著升高.
- 后勤回归确定IL-13和骨周蛋白质是CRSwNP骨炎的重要风险因素,IL-13显示出高预测值 (AUC=0.786).
结论:
- 在CRSwNP中,骨炎可能意味着更严重的疾病表现.
- 增加IL-13,骨周蛋白质和组织乙氨基酸被确定为CRSwNP患者骨炎发展的危险因素.
- 这些发现突显了2型炎症在CRSwNP骨质炎病原体中的作用.
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