孕妇患有甲状腺功能低下症的SARS-CoV-2感染
Madalina Daniela Iordache1, Daniela Catalina Meca1, Monica Mihaela Cirstoiu1
1Department of Obstetrics and Gynaecology, University Emergency Hospital Bucharest, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染在患有甲状腺功能低下症的孕妇中并没有增加早产或低出生体重的风险. 然而,在这个群体中观察到死产的风险更高.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与增加的孕产妇和胎儿风险有关.
- 病毒感染可能会加剧自身免疫性疾病,可能会使自身免疫性甲状腺炎和甲状腺功能低下症的妇女的妊娠并发症恶化.
研究的目的:
- 为了调查SARS-CoV-2感染与甲状腺功能低下症相结合是否会增加不良妊娠结果.
- 在SARS-CoV-2感染期间,在患有甲状腺功能低下症和没有甲状腺功能低下症的孕妇之间识别孕妇和胎儿参数的差异.
主要方法:
- 研究了一组145名感染SARS-CoV-2的孕妇.
- 参与者被分为两个组:有和没有自身免疫性甲状腺炎和甲状腺功能低下症.
- 分析了母亲和胎儿的人口,实验室和结果参数.
主要成果:
- 在SARS-CoV-2阳性孕妇中,甲状腺功能低下的患病率为8.96%.
- 对于胎儿体重,阿普加尔评分,新生儿重症监护室入院或子宫内生长限制,两组之间没有发现显著的相关性.
- 在甲状腺功能低下症组中发生了一例死产;甲状腺病理没有恶化病毒感染的进展.
结论:
- SARS-CoV-2 感染和甲状腺功能低下症似乎不会增加早产,子宫内生长限制或胎儿体重低的风险.
- 在SARS-CoV-2阳性怀孕中,甲状腺功能低下症和死产风险增加之间存在潜在的关联.
- 这些患者的甲状腺功能低下与尿酸水平降低和INR值略有降低相关.
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