左心室辅助器件和中风患者的性别差异
Salma Zook1, Otito Ojukwu2, Safi U Khan1
1Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, USA.
JACC. Advances
|June 28, 2024
概括
带有左心室辅助装置 (LVAD) 植入器的男性经历了恶化的中风趋势和更高的并发症负担. 妇女的LVAD较少,患出血性中风的风险更高,突出了基于性别的临界结果差异.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 与左心室辅助器件 (LVAD) 相关的中风患者中临床结果的性别差异没有得到很好的描述.
- 了解这些差异对于改善患者护理和结果至关重要.
研究的目的:
- 检查在LVAD住院期间发生中风的患者临床特征和临床结果的基于性别的差异.
- 确定男性和女性中风发病率和相关因素的趋势.
主要方法:
- 利用国家住院患者样本 (2010-2019) 来识别LVAD住院期间中风患者.
- 分析了住院患者的死亡率和临床并发症,比较男性和女性.
- 用人加权后勤回归,调整年龄和埃利克沙瑟并发症指数.
主要成果:
- 经历中风的女性比男性 (59岁) 年轻 (51岁).
- 男性的伴随性疾病负担更高;女性患出血性中风的几率更高 (OR:1.49).
- 2010-2019年间,中风率在男性中显著增加,而女性的趋势则有所不同.
结论:
- 男性在LVAD植入后表现出更高的并发症负担和恶化的中风趋势.
- 女性,尽管LVAD较少,但出血性中风的发病率较高.
- 在针对性干预方面,解决LVAD中风患者的性别相关结果差异至关重要.
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