对新型生物活性剂在侵蚀的面膜损伤上的重矿化潜力的比较评估:一项单盲实验室研究
Mansi Behl1, Sonali Taneja1, Vidhi Kiran Bhalla1
1Department of Conservative Dentistry and Endodontics, Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.
Journal of conservative dentistry and endodontics
|June 28, 2024
概括
与其他药物相比,自我组装的P-114显著改善了牙面膜的重矿化和硬度. 这一发现凸显了它在治疗酸性饮料引起的牙侵蚀方面的潜力.
科学领域:
- 牙科科学 牙科科学
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
背景情况:
- 无病性牙磨损,特别是酸性饮料造成的牙侵蚀,是一个越来越令人担忧的问题.
- 酸性条件降低了牙质,导致表面损失和牙完整性降低.
- 有效的再生矿物质化方案对于控制牙侵蚀至关重要.
研究的目的:
- 评估自我组装P-114 (SAP P-114) 在重新矿化牙质中的有效性.
- 为了比较SAP P-114与酸酸盐化物 (CPP-ACPF) 和Biomin F.与酸酸盐化物 (CPP-ACPF) 的结合物.
- 评估这些剂对质微硬度和化学成分的影响.
主要方法:
- 使用了73个质样本,其中包括对照组,CPP-ACPF,Biomin F和SAP P-114.
- 标本经历了为期5天的去矿化-再矿化循环.
- 评估包括维克斯微硬度测试,EDX分析和扫描电子显微镜 (SEM).
主要成果:
- 在SAP P-114组中,微硬度的平均百分比变化最低 (12.08%),表明保护优越.
- 在SAP P-114组的Ca/P比率 (2.01) 最接近基线 (2.20),表明有效的矿物回收.
- 与对照组相比,所有测试剂都显示出了统计学上显著的改善.
结论:
- 自组合P-114在重新矿物化牙面膜方面表现出卓越的有效性.
- 这些发现支持SAP P-114在治疗牙侵蚀方面的潜在临床应用.
- 建议进行进一步的体内研究,以验证这些有希望的结果.
更多相关视频
08:12Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
10.1K
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
6.3K
相关概念视频
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Microbial Bioremediation of Hydrocarbons
Bioremediation is an environmentally sustainable process that employs living organisms—primarily microorganisms—to degrade or neutralize pollutants from contaminated environments. In oil spills and hydrocarbon pollution, bioremediation involves the use of hydrocarbon-degrading bacteria to transform toxic compounds into less harmful substances. This approach leverages natural microbial metabolic processes and is considered both cost-effective and ecologically favorable compared to physical or...
