更新的全球流行病学图谱人类病
Li-Ping Gao1, Ting-Ting Tian1, Kang Xiao1
1National Key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, National Health Commission Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Frontiers in public health
|June 28, 2024
概括
全球人类病 (PrD) 病例呈现上升趋势,在1993年至2020年期间报告了超过27,000例. 监测至关重要,特别是许多低收入国家缺乏报告,可能低估了这些致命的神经退行性疾病的真正全球负担.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 人类病 (PrD) 是致命的,可传播的神经退行性疾病,包括克鲁茨菲尔特-雅各布病 (CJD).
- 牛形脑病变 (BSE) 和变异性CJD (vCJD) 的出现加剧了公共卫生方面的担忧.
- 自20世纪90年代以来,PrD监控计划已在全球范围内实施.
研究的目的:
- 分析1993年至2020年人类病 (PrD) 病例数的全球和特定国家的趋势.
- 为了确定27年的地理分布和PrD发病率的变化.
- 评估全球PRD监控的完整性.
主要方法:
- 从国际和国家PrD监控计划和出版物收集数据.
- 对各种PrD类型的报告病例数和趋势的分析.
- 对不同收入水平国家的监控工作进行比较.
主要成果:
- 在34个国家报告了总共27,872例PrD病例,其中零星CJD (sCJD) 占大多数 (24,623例).
- 美国,法国,德国,意大利,中国,英国,西班牙和加拿大报告了最多的PRD病例.
- 在27年的时间里,在全球和许多国家观察到每年PrD病例和死亡率的增加趋势.
结论:
- 人类普里昂病监测主要在高收入国家进行,这表明全球普里昂病例被严重低估.
- 遗传性PrD占病例的10.83%,在不同地区存在显著差异.
- 对人类和动物的PrD进行持续的国际监测对于保护公共健康至关重要.
相关概念视频
Amyloid Fibrils
9.5K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.5K
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K
Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K


