在土著人口中估计高胆固醇血症的患病率:系统性审查和元分析
Rylan K McCallum1,2,3, Adam I Kramer3, Miles Marchand1,4
1Centre for Heart and Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
JACC. Advances
|June 28, 2024
概括
高胆固醇血症影响着大约三分之一的土著人,有助于高动脉样硬化心血管疾病 (ASCVD) 率. 需要对这些人群中严重和家族性高胆固醇血症进行更多的研究.
科学领域:
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
- 土著健康研究土著健康研究
背景情况:
- 高胆固醇血症,标志着高的LDL-C,提高ASCVD的风险.
- 原住民人口面临不成比例的高ASCVD率.
- 高胆固醇血症在这种差异中的作用尚不清楚.
研究的目的:
- 确定加拿大,美国,澳大利亚和新西兰土著人口中高胆固醇血症的患病率.
- 评估严重高胆固醇血症和家族性高胆固醇血症 (FH) 的患病率.
主要方法:
- 在多个数据库 (MEDLINE,EMBASE等) 进行系统的文献搜索. ) 的情况.
- 包括报告高胆固醇血症和在土著人口中增加的LDL-C的研究.
- 用于聚合流行率计算的随机效应建模.
主要成果:
- 高胆固醇血症的综合患病率为28.9% (约. 1 在 3 到 1 在 4).
- 流行率因地区而异:北美为24.3%,澳大利亚为40.0%.
- 糖尿病显著影响高胆固醇血的患病率 (P=0.022).
- 没有研究报告FH患病率;只有一个报告严重的高胆固醇血症.
结论:
- 高胆固醇血症在土著社区很常见,可能有助于ASCVD负担.
- 在全球的土著人口中,关于FH和严重高胆固醇血症的研究存在显著的差距.
相关概念视频
Cholesterol: Significance and Regulation
535
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
535
Lipids: Dietary Sources and Requirements
720
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
720
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
635
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
635
Blood Studies for Cardiovascular System III: Serum Lipid Profile
154
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
154
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.2K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.2K


