在患有先天性心脏病的成年人中出现失脂症
Fred M Wu1,2, Michael E Mendelson1, Yisong Huang1
1Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
JACC. Advances
|June 28, 2024
概括
患有先天性心脏病 (CHD) 的成年人患有高患病率的失脂症,这种疾病的特征是胆固醇水平异常. 定期的脂质查对于这一群体的预防性护理至关重要.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 动脉样硬化疾病对患有先天性心脏病 (CHD) 的成年人构成重大健康风险.
- 血脂缺血的患病率,一种涉及血脂水平异常的疾病,在患有心脏病的成年人中没有得到充分的证据.
研究的目的:
- 为了确定患有先天性心脏病的成年患者中脱脂症的患病率.
- 为了确定与心脏病复杂性相关的特定脂质异常.
主要方法:
- 一项前性门诊查研究,涉及4个新英格兰中心的186名患有心血管疾病的成年人 (≥18岁).
- 参与者接受了心血管风险因素调查和非禁食指针脂质分析,使用临床检测.
主要成果:
- 近一半 (46%) 的参与者符合失脂血症的定义.
- 低高密度脂蛋白胆固醇 (HDL-C) 在32%,高非HDL-C在34%,高总胆固醇 (TC) 在20%观察到.
- 较高的TC水平与简单的CHD有关,而较低的HDL-C水平与复杂的CHD有关.
结论:
- 在患有心血管疾病的成年人中,失脂症非常普遍,往往未被诊断出来.
- 脂质查应纳入常规预防性医疗保健中,以管理心血管风险.
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