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非信号外细胞间隔器调节CAR T细胞的瘤抗原选择性

Kelly T Kennewick1, Yukiko Yamaguchi1, Jackson Gibson1

  • 1Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.

Molecular therapy. Oncology
|June 28, 2024
PubMed
概括

优化化学抗原受体 (CAR) T细胞治疗固体瘤包括调整细胞外间隔器. 间隔器设计影响CAR T细胞选择性,增强对抗高抗原瘤的疗效,同时保护健康组织.

关键词:
汽车 汽车 汽车 汽车在HER2中,HER2是HER2.MT: 定期发行 定期发行这是PSCA的PSCA.通过T细胞免疫疗法进行的免疫治疗.乳腺癌 乳腺癌 乳腺癌仿制性抗原受体的仿制性抗原受体没有信号的细胞外间隔域域.前列腺癌是前列腺癌.

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