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胃绕道和袖子胃切除术对骨矿物质密度的长期差异影响
Pierre-Emmanuel Cailleaux1,2, Agnès Ostertag2, Didier Albert Haguenauer1
1Service de gériatrie aiguë, Hôpital Louis-Mourier, Assistance Publique-Hôpitaux de Paris, F-92700 Colombes, France.
Journal of the Endocrine Society
|June 28, 2024
概括
减肥手术对骨密度的影响因手术不同而有所不同. 长期,特定的生物标志物显示,手术后与骨矿物质密度的联系很弱.
科学领域:
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
- 代谢手术 代谢手术
背景情况:
- 肥胖与骨脆弱有关,但减肥手术 (BS) 虽然有效减肥,但可能会对骨健康产生负面影响.
- 关于BS后长期骨并发症的风险因素的信息有限.
研究的目的:
- 在Roux-en-Y胃绕道 (RYGB) 和袖子胃切除术 (SG) 几年后,调查与低骨矿物质密度 (BMD) 相关的因素.
主要方法:
- 在手术后至少6.8年的131名患者 (91名RYGB,40名SG) 的横截面研究.
- 双能X射线吸收度 (DXA) 和生物因素 (维生素,微量营养素,骨和炎症生物标志物) 的评估.
- 使用简单和多重线性模型进行统计分析.
主要成果:
- 与SG组相比,RYGB组的骨髓质量显著降低,尽管体重减轻类似,但在所有地点的骨髓质量显著降低.
- 在RYGB患者中观察到较高的血清副甲状腺激素和酸盐水平.
- 多变量分析证实了手术组之间的BMD差异,血清,费里丁和尿酸与BMD的联系很弱.
结论:
- 骨矿物质密度结果根据所进行的减肥手术类型 (RYGB vs SG) 有显著差异.
- 某些生物标志物在减肥手术后的长期内可能与BMD有轻微,微弱的关联.
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