内皮细胞功能障碍:开始,进展和后果
Hojjat Naderi-Meshkin1, Wiwit Ananda Wahyu Setyaningsih1,2
1The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, UK.
Frontiers in bioscience (Landmark edition)
|June 28, 2024
概括
内皮细胞功能障碍是由众多因素引起的,经历不同的阶段,并产生重大健康后果. 了解这个复杂的过程是开发心血管疾病有效治疗策略的关键.
科学领域:
- 心血管科学 心血管科学
- 细胞生物学 细胞生物学
- 病理生理学 病理生理学
背景情况:
- 内皮细胞功能障碍是心血管疾病的关键因素.
- 它涉及原因,早期/晚期事件和后果的复杂相互作用.
研究的目的:
- 为提供内皮细胞功能障碍的全面概述.
- 概述针对功能障碍各个阶段的治疗干预措施.
主要方法:
- 本综述综合了关于内皮细胞功能障碍的现有文献.
- 它检查了原因,进展,后果和治疗策略.
主要成果:
- 原因包括高血压,糖尿病,吸烟,肥胖,炎症,氧化应激和遗传.
- 早期事件涉及激活和炎症;晚期事件包括亡和稀缺.
- 后果包括重塑,新血管化,器官功能障碍和临床表现.
结论:
- 内皮细胞功能障碍是一个由多个因素影响的动态过程.
- 量身定制的治疗干预措施对于减轻其对健康和心血管疾病进展的影响至关重要.
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