基于光谱动态因果建模的轻度认知障碍帕金森病默认模式网络子系统的有效连接性
TianTian Pan1, Hang Qu1, Yu Pan1
1Department of Radiology, Medical Imaging Center, The Affiliated Hospital of Yangzhou University, Yangzhou University, 225009 Yangzhou, Jiangsu, China.
Journal of integrative neuroscience
|June 28, 2024
概括
轻度认知障碍 (PD-MCI) 的帕金森病显示出改变的默认模式网络 (DMN) 连接. 这些DMN变化,特别是在中部前额叶皮和角性环,可能是PD-MCI患者认知缺陷的基础.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病.
- 轻度认知障碍 (MCI) 在PD患者 (PD-MCI) 中很常见.
- 默认模式网络 (DMN) 对认知功能至关重要,并与神经退行性疾病有关.
研究的目的:
- 为了比较DMN子系统PD-MCI和认知正常PD (PD-CN) 患者之间的有效连接.
- 调查PD-MCI中DMN功能障碍的机制.
- 探索DMN连接性和PD-MCI中的认知功能之间的关联.
主要方法:
- 功能磁共振成像 (fMRI) 静止状态数据使用光谱动态因果建模 (spDCM) 分析.
- 在23名PD-MCI和22名PD-CN患者中评估了DMN子系统 (MPFC,PCC,LAG,RAG) 的有效连接.
- 使用两个样本t测试和与蒙特利尔认知评估 (MoCA) 成绩的相关性分析进行统计比较.
主要成果:
- 在PD-MCI与PD-CN组中,MPFC-LAG (t = -2.993,p < 0.05) 和LAG-PCC (t = 2.174,p < 0.05) 之间发现了有效连接性的显著差异.
- 这些发现表明PD-MCI中DMN内的功能通信发生了变化.
结论:
- 患有PD-MCI的患者在DMN子系统中表现出异常有效的连接.
- 鉴定到的连接性改变可能会导致PD-MCI中观察到的认知障碍.
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