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相关概念视频

Phylogenetic Trees03:21

Phylogenetic Trees

45.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.3K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.1K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Phylogeny01:23

Phylogeny

43.8K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
43.8K
RNA Editing02:23

RNA Editing

9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

10.6K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
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相关实验视频

Updated: Jun 22, 2025

A Bioinformatics Pipeline to Accurately and Efficiently Analyze the MicroRNA Transcriptomes in Plants
06:34

A Bioinformatics Pipeline to Accurately and Efficiently Analyze the MicroRNA Transcriptomes in Plants

Published on: January 21, 2020

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在RNA树上,中小的节问题.

Bertrand Marchand1, Yoann Anselmetti1, Manuel Lafond1

  • 1Department of Computer Science, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

Bioinformatics (Oxford, England)
|June 28, 2024
PubMed
概括

我们开发了新的树距离指标来分析非编码RNA (ncRNA) 结构,帮助研究RNA的进化和功能. 这些方法提供了对RNA结构保护和家族和族群内的分歧的更深入的了解.

科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 分子进化分子进化

背景情况:

  • 非编码RNAs (ncRNAs) 通过特定的分子结构来执行功能.
  • RNA二级结构在功能性家族内保存,而三级结构在RNA氏族内可能有所不同.
  • 了解RNA结构演变是解读功能适应和古代RNA世界假设的关键.

研究的目的:

  • 引入和分析树距离指标,以推断非编码RNA结构的演变.
  • 用新型和现有的树距离来解决ncRNA家族的中位数和小节问题.
  • 为重建RNA进化史开发高效的算法.

主要方法:

  • 代表ncRNA二次结构作为叶子标记树.
  • 使用罗宾逊-福尔德斯 (RF) 树距离,并引入内部-叶片 (IL) 距离.
  • 考虑非完美对齐的基数对的概括树编辑距离.
  • 分析理论复杂性和开发多项式时间最大共存算法.

主要成果:

  • 与射频距离相比,IL距离更好地捕捉了RNA结构元素的差异.
  • 在不同的距离指标下,研究了中等和小钱问题的理论复杂性.

更多相关视频

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

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Improving Small RNA-seq: Less Bias and Better Detection of 2'-O-Methyl RNAs
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Improving Small RNA-seq: Less Bias and Better Detection of 2'-O-Methyl RNAs

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相关实验视频

Last Updated: Jun 22, 2025

A Bioinformatics Pipeline to Accurately and Efficiently Analyze the MicroRNA Transcriptomes in Plants
06:34

A Bioinformatics Pipeline to Accurately and Efficiently Analyze the MicroRNA Transcriptomes in Plants

Published on: January 21, 2020

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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

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Improving Small RNA-seq: Less Bias and Better Detection of 2'-O-Methyl RNAs
08:49

Improving Small RNA-seq: Less Bias and Better Detection of 2'-O-Methyl RNAs

Published on: September 16, 2019

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  • 开发了多项式时间最大储蓄算法,并应用于ncRNA家族.
  • 通过应用到RFAM数据库的ncRNA家族来证明实际的实用性.
  • 结论:

    • 新型树距离指标为研究ncRNA结构演变提供了有价值的工具.
    • 有效的算法可以帮助重建RNA家族和族群的进化历史.
    • 这项研究增强了我们对RNA功能适应和进化过程的理解.