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相关概念视频

RNA Interference01:23

RNA Interference

26.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

6.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.1K
Nucleic Acids02:43

Nucleic Acids

44.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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RNA-seq03:21

RNA-seq

9.9K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.9K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

13.2K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
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相关实验视频

Updated: Jun 22, 2025

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
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An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA

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一部分RNA设计.

Frederic Runge1, Jörg Franke1, Daniel Fertmann1

  • 1Department of Computer Science, University of Freiburg, Freiburg 79110, Germany.

Bioinformatics (Oxford, England)
|June 28, 2024
PubMed
概括
此摘要是机器生成的。

本研究介绍了部分RNA设计,一种用于创建功能性RNA分子的新计算方法. 开发的算法libLEARNA有效地设计具有特定属性和约束的RNA,从而推进合成生物学应用.

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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA
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相关实验视频

Last Updated: Jun 22, 2025

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
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An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA

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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA
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Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA

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科学领域:

  • 计算生物学 计算生物学
  • 合成生物学 合成生物学
  • 生物技术是生物技术.

背景情况:

  • RNA设计对于开发合成生物学和生物技术中的新功能至关重要.
  • 目前的计算RNA设计工具在定义RNA序列的搜索空间方面存在局限性.

研究的目的:

  • 提出一种新的RNA设计范式,部分RNA设计,以克服现有方法的局限性.
  • 引入一个高效的算法,libLEARNA,用于解决约束RNA设计任务.

主要方法:

  • 开发了一种新的RNA设计配方,称为部分RNA设计.
  • 将设计空间与目标分开,以允许可变的RNA长度和所需的特性.
  • 介绍了libLEARNA算法来解决各种约束RNA设计问题.

主要成果:

  • 证明了部分RNA设计在解决当前配方局限性的有效性.
  • libLEARNA有效地解决了不同的约束RNA设计任务.
  • 综合分析,包括一个带状开关设计任务,显示了libLEARNA的卓越性能和稳定性.

结论:

  • 部分RNA设计为RNA序列和结构设计提供了一种灵活而精确的方法.
  • libLEARNA是用于计算RNA设计的强大而稳健的工具.
  • 开发的方法和算法提升了创建功能性RNA分子的能力.