在儿童单症状夜间尿尿失调的自治神经系统失调
Maria Angeli1, Maria Bitsori1,2, Sophia E Schiza3
1School of Medicine, University of Crete, Heraklion, Greece.
Acta paediatrica (Oslo, Norway : 1992)
|June 28, 2024
概括
自主神经系统功能障碍影响儿童尿尿失常. 夜间多尿症涉及同情性多动性,而非多尿性尿尿症与副交感性过度刺激和膀过度活动有关.
科学领域:
- 儿科脏病学 儿科脏病学
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 童年尿是常见的,其潜在机制通常与自主神经系统 (ANS) 失调有关.
- 尿尿症的亚型,特别是带有和没有夜间多尿症的亚型,可能会表现出涉及ANS的明显的病理生理路径.
研究的目的:
- 研究自主神经系统在患有夜间尿尿症的儿童的不同亚群中的作用.
- 为了区分患有夜间多尿症的尿尿症的儿童与没有夜间多尿症的儿童的ANS贡献.
主要方法:
- 研究了一组35名尿儿童 (17名夜间多尿症,18名没有) 和43名健康对照组.
- 评估了荷尔蒙和神经递质水平,通过睡眠追踪器的睡眠模式,24小时血压监测,夜间尿液输出和尿液流量计.
主要成果:
- 与对照组相比,尿尿症患者的儿童表现出较低的可佩和阿尔多;在非多尿症组中,阿尔多降低更为明显.
- 与夜间多尿症相比,没有夜间多尿症的儿童的多巴胺水平较低.
- 在非多尿症组的NREM睡眠期间,在多尿症组的REM和NREM睡眠期间都发生了尿液发作. 在尿尿症儿童中观察到不下降的血压模式,在非多尿症组中更为如此.
结论:
- 带有夜间多尿症的夜间尿尿与交感性过活,压力多尿症和睡眠期间降低缩血压有关.
- 没有夜间多尿症的夜间尿泡似乎与来自对交感过度刺激的膀过度活跃有关,由NREM相关的情节和较低的阿尔多素/多巴胺水平证明.
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