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身体肥胖与左心室同心重塑和扩张功能障碍的关联

In-Jeong Cho¹, Sang-Eun Lee¹, Wook Bum Pyun¹

¹Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, South Korea.

Echocardiography (Mount Kisco, N.Y.)

|June 28, 2024

概括

副心脏脂肪组织 (EAT),而不是内脏 (VAT) 或皮下 (SAT),在保存的喷射分数心力衰竭中显著影响心脏结构和功能. 厚厚的EAT与心脏腔更小和重塑有关.

科学领域:

心脏病学心脏病学
肥胖问题研究研究
医疗成像医学成像

背景情况:

肥胖是心力衰竭的关键危险因素之一,心力衰竭的危险因素包括心脏射分数 (HFpEF).
了解不同脂肪组织储存对心脏结构和功能的影响,对于HFpEF管理至关重要.
这项研究研究了身体质量指数 (BMI) 和脂肪组织部分 (VAT,SAT,EAT) 与左心室 (LV) 特性之间的关系.

研究的目的:

检查BMI,VAT,SAT和EAT与LV结构和功能之间的关联.
确定哪个脂肪组织储存对心脏重塑和心脏功能产生最显著的影响,在维护LV缩功能的人群中.

主要方法:

对749名参与者进行了回顾性分析,这些参与者保持了LV缩功能.
为了获取数据,利用过胸腔心声学和腹部计算机断层扫描.
评估了LV的结构和功能参数,以及EAT,VAT和SAT厚度.

主要成果:

皮下脂肪组织 (SAT) 随着年龄的增长而减少,而内脏脂肪组织 (VAT) 和上心脂肪组织 (EAT) 增加.
BMI与SAT的相关性最强,其次是增值税和EAT.
经过对临床变量进行调整后,心上脂肪组织 (EAT) 显示出与不良LV重塑的最显著的关联,包括房间尺寸的减少和相对壁厚的增加. 增值税和SAT没有显示显著的关联.

结论:

心脂肪组织 (EAT) 是最具影响力的脂肪组织在改变 LV 几何和功能.
增加的EAT与较小的LV腔体大小,同心重塑和减弱的放松有关,这有助于HFpEF病理生理学.

关键词:

脂肪组织的脂肪组织.功能功能功能功能.在左心室的左心室.结构结构结构结构

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