风险因素和左心室缩的预测模型在年轻的成年人与盐敏感高血压
Jindong Wan1,2, Peijian Wang3, Sen Liu3
1Research Center for Metabolic and Cardiovascular Diseases, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal of clinical hypertension (Greenwich, Conn.)
|June 28, 2024
概括
一种新的名图有效预测左心室缩 (LVH) 风险的年轻人与盐敏感高血压. 该工具使用常规的临床变量来早期识别高风险个体.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 预防医学 预防医学
背景情况:
- 对盐敏感的高血压在基本高血压病例中很普遍.
- 左心室缩 (LVH) 的患病率正在增加.
- 在盐敏感高血压的年轻成年人中缺乏早期识别LVH风险.
研究的目的:
- 开发一种用于预测盐敏感高血压的年轻成年人LVH风险的诺米克图.
- 为高风险个人提供早期识别工具.
主要方法:
- 对580名盐敏感高血压患者的回顾性分析.
- 基于训练集的多变量分析 (n=406) 开发了一个名图.
- 使用单独的验证集 (n=174) 验证名录的验证.
主要成果:
- 开发了一种简化的名图,包括年龄,性别,静脉压,高血压持续时间,腹部肥胖,甘油三指数和eGFR.
- 该名图显示了中度的歧视 (ROC AUC = 0.863) 和训练组中的良好校准.
- 验证证实了nomogram的可靠性和临床实用性.
结论:
- 使用七个常规临床变量进行简化的名图,可以有效地识别 LVH 风险较高的盐敏感高血压的年轻人.
- 诺米图提供了良好的预测性能和临床实用性,用于早期LVH风险评估.
- 该工具有助于在风险年轻人群中早期发现和管理LVH.
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