COVID-19疫苗接种对多发性硬化症活动的影响,如MRI所反映的
Esther Ganelin-Cohen1,2, Chen Buxbaum3, Noam Bosak3
1Neuroimmunological Clinic, Institute of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Brain and behavior
|June 28, 2024
概括
在大多数多发性硬化症 (MS) 患者中,BNT162b2 COVID-19 疫苗似乎是安全的. 然而,早期发病的多发性硬化症患者需要在接种疫苗后密切监测MRI,因为可能增加新病变的风险.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在多发性硬化症 (MS) 患者中,BNT162b2 mRNA 疫苗的安全性尚未完全确立,特别是在潜在的疾病恶化方面.
- 这项研究调查了BNT162b2COVID-19疫苗接种对MS疾病活性的影响,使用连续MRI扫描.
研究的目的:
- 评估BNT162b2 mRNA疫苗在多发性硬化症患者中的安全性和有效性.
- 评估BNT162b2疫苗接种与MS疾病活动,特别是新病变形成之间的关联.
主要方法:
- 来自以色列五家医院的84名多发性硬化症患者的回顾性分析.
- 脑部MRI扫描被用来评估病变负载,其中一个扫描是接种疫苗后的,两个是接种疫苗前的.
- 亚组分析比较了接种疫苗和未接种疫苗的患者,包括早期发病的MS患者.
主要成果:
- 该研究包括70名患有早期发病 (平均年龄16.4岁) 和成人发病 (平均年龄34.9岁) 多发性硬化症的妇女.
- 接种疫苗的早期发病的多发性硬化症患者显示,新病变的风险显著增加 (p=0.00026).
- 在接种疫苗后,在成人发病的MS患者中没有观察到新病变的风险增加.
结论:
- 对于大多数MS患者来说,BNT162b2疫苗通常是安全的,没有与新病变的广泛联系.
- 建议在疫苗接种后对早期发病的MS患者进行密切的MRI随访,以监测病变的发展.
相关概念视频
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
01:27Imaging Studies IV: Magnetic Resonance Imaging
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...