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相关概念视频

Desmosomes01:05

Desmosomes

5.3K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
5.3K
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

25.4K
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
25.4K
Anchoring Junctions01:03

Anchoring Junctions

3.7K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.7K
Plasmodesmata01:20

Plasmodesmata

2.8K
In a multicellular organism, cells must communicate to work together in a coordinated manner. One way that cells communicate is through direct contact with other cells. The points of contact that connect adjacent cells are called intercellular junctions.
Intercellular junctions are a feature of fungal, plant, and animal cells. However, different types of junctions are found in different kinds of cells. Intercellular junctions found in animal cells include tight junctions, gap junctions, and...
2.8K
Adherens Junctions01:24

Adherens Junctions

4.7K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
4.7K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.0K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.0K

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PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence.

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Failed Metabolic Adaptation to Stress Underlies Pathogenesis in a Heterozygous Genetic Disorder.

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Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.

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相关实验视频

Updated: Jun 22, 2025

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
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Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

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在一眼看的Desmosomes.

Abbey L Perl1, Jenny L Pokorny1, Kathleen J Green1,2,3

  • 1Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Journal of cell science
|June 28, 2024
PubMed
概括

德斯莫索姆是动态的细胞结点,对组织完整性至关重要,特别是在机械应力下. 它们感知并响应环境线索,影响细胞过程和疾病.

科学领域:

  • 细胞生物学 细胞生物学
  • 生物化学 生物化学
  • 生物物理学的生物物理.

背景情况:

  • 德斯莫索姆是基于卡德林的细胞-细胞结点,对于脊椎动物组织的结构完整性至关重要.
  • 它们将中间线丝细胞骨架与细胞结合点连接起来,抵消来自附着结合点的力量.
  • 在经历高机械应力的组织中至关重要,如皮肤和心脏.

研究的目的:

  • 为了审查desmosome结构,组装和功能.
  • 突出了解表皮中的desmosome机械化学信号的见解.
  • 讨论desmosomes作为人类疾病的治疗目标.

主要方法:

  • 关于desmosome研究的文献综述.
  • 对德斯莫索姆结构和组装机制的分析.
  • 检查依赖于代体的信号通路.

主要成果:

  • 德斯莫索姆是动态的,而不是静态的结构.
  • 它们在响应环境刺激时整合化学和机械信号.
  • 德斯莫索姆功能障碍与各种人类疾病有关.

结论:

关键词:
细胞粘附 细胞粘附细胞力学 细胞力学细胞骨架 细胞骨架皮肤表皮的信号传递细胞间连接点是细胞间的连接点.皮肤 皮肤 皮肤 皮肤

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  • 德斯莫索姆在组织力学和细胞反应中起着至关重要的作用.
  • 了解德斯莫索姆信号传递为疾病治疗提供了潜力.
  • 对德斯莫索姆动态的进一步研究是有必要的.