长期COVID对儿童肺功能的影响
Zeynep Reyhan Onay1, Sinem Can Oksay1, Deniz Mavi Tortop1
1Istanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, Türkiye.
Medeniyet medical journal
|June 28, 2024
概括
在COVID-19后持续的呼吸道症状在儿童中很常见. 肺功能测试,如螺旋计,对于监测至关重要,但FeNO测试对于儿童的长期COVID评估并不有效.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 由于COVID-19的流行,儿童在感染后出现持续的呼吸道症状的数量增加了.
- 虽然在儿童中通常较温和,但长期的呼吸系统后果需要进行彻底的调查.
研究的目的:
- 评估COVID-19后长期出现呼吸道症状的儿童的肺功能.
- 为了比较COVID-19幸存者和健康对照者之间的肺功能测试结果.
主要方法:
- 一项前性,单中心的队列研究,涉及55名长期COVID患者和55名健康对照儿童.
- 肺功能测试包括螺旋计,6分钟步行测试 (6MWTs),肺体积,一氧化碳 (DLCO) 的扩散能力和部分呼出的氧化 (FeNO).
- 在COVID-19感染后至少4周进行了评估.
主要成果:
- 长期COVID的儿童中,限制性肺功能模式更为普遍 (p=0.021).
- 患有长期COVID的儿童的6MWT距离,DLCOZ分数和预测的螺旋计/肺体积显著降低,尽管结果保持在正常范围内.
- 对于DLCO,FeNO和6MWT的平均预测值在各组之间是相似的.
结论:
- 儿童在COVID-19后长期出现的呼吸道症状需要全面评估.
- 螺旋计和肺体积评估对于监测COVID-19后患有呼吸系统异常的儿童至关重要.
- 断片呼出的氧化 (FeNO) 测量被发现是无效的监测长期COVID在这个儿科队列.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:17Pulmonary Cycle: Exhalation
1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:24Cystic Fibrosis: Management
154
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
154
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K