早期月经作为对心血管事件的保护因素:系统性审查和元分析
Clinton Sudjono1, Kiara Hanna Quinncilla2, Ms Qonita3
1Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.
早期初潮与女性较低心血管疾病 (CVD) 事件有关. 初经晚年可能是心血管疾病的重要风险因素,需要在风险评估中考虑.
科学领域:
- 心血管健康 心血管健康
- 生殖流行病学 生殖流行病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 的预防往往忽视了妇女的具体健康需求.
- 初潮时的年龄 (AAM) 是女性心血管疾病的潜在风险因素,但综合证据有限.
- 这项研究探讨了初潮早期对各种心血管结果的影响.
研究的目的:
- 系统地审查和元分析早期初潮和心血管结果之间的关联.
- 研究初潮早期对全因死亡率,心血管疾病死亡率,心血管疾病总发生率,中风和冠心病 (CHD) 的影响.
- 确定初潮时的年龄作为女性潜在的心血管疾病风险因素.
主要方法:
- 对队列研究进行系统审查和元分析.
- 从2013年3月到2023年3月,搜索了多个数据库 (科克兰图书馆,MEDLINE,Embase,ScienceDirect,谷歌学者).
- 包括至少5年随访的队列,不包括针对特定人群或先前存在的CVD的研究.
主要成果:
- 分析了13个群体,包括超过1860万名女性.
- 早期初潮与较低的冠心病 (CHD),总中风,心血管疾病死亡率,总心血管疾病事件,缺血性中风和出血性中风的发生率显著相关.
- 在初潮早期的妇女中,全因死亡率不大.
结论:
- 发现初潮早期的女性心血管事件的发生率较低.
- 晚期初潮时的年龄成为心血管疾病 (CVD) 的潜在危险因素.
- 需要进一步的研究来探索混的荷尔蒙因素并澄清心血管疾病的结果.
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